EVALUATION OF MICROCYTIC HYPOCHROMIC ANEMIA BY ELECTROPHORESIS FOR HEMOGLOBINOPATHIES IN YOUNG POPULATION

Objectives: Hemoglobinopathies are serious genetic blood disorders requiring lifelong transfusions and treatment in its most severe chronic form. If undiagnosed or untreated, these ultimately lead to death. South Asia especially India, Pakistan, Bangladesh has high populations of hemoglobinopathies. In there an estimated 100,000 thalassemia majors patients nearly 3.5 4 million carriers this disorder. Tribal India have a range 5–40% sickle cell anemia (SCA) sufferers. The aim the study was detect hemoglobinopathies by electrophoresis microcytic hypochromic young population area covered tertiary care center at Index Medical College Hospital. Methods: A cross-sectional carried out hospital rural Indore on (10–30 years age group) who attended outpatient department from June 2018 March 2020. Total 517 cases moderate were included study. All subjected series hematological investigations, which include complete hemogram, peripheral smear, some standard procedures. Sysmex XS800i fully automated Cell counter used for count. It is 5-part differential instrument. reports all five subpopulations, namely, neutrophils, eosinophils, basophils, monocytes, lymphocytes. smear test look abnormalities cells. Results: study, 34.4% positive Hb 65.6% negative. On electrophoresis, number 34.3%, trait – 20.8%, beta-thalassemia 29.8% major observed. hemoglobinopathies, 73 females, 28.8% having trait, 27.4% SCA 23.3% beta-thalassemia, 20.5% trait. Of 105 males, 30.5% 9.5% 39.0% SCA, 21.0% Conclusion: ANMs, ASHA, Anganwadis should be taught about importance screening So that they can explain purpose female during pregnancy families areas. At primary level, CHCs PHCs equipped with instruments basic testing